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Publications

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Peer-reviewed publications

  1. Conformational changes in the Niemann-Pick Type C1 protein NCR1 drive sterol translocation.

    Frain KM*, Dedic E*, Nel L*, Bohush A, Olesen E, Thaysen K, Wüstner D, Stokes D, Pedersen BP.
    Proc Natl Acad Sci U S A. 121(15):e2315575121 (2024).
    (PubMed)

  2. Structure and Function of Auxin Transporters.

    Hammes UZ, Pedersen BP.
    Annual Review of Plant Biology Online ahead of print, (2024).
    (PubMed)

  3. Slow release of a synthetic auxin induces formation of adventitious roots in recalcitrant woody plants.

    Roth O, Yechezkel S, Serero O, Eliyahu A, Vints I, Tzeela P, Carignano A, Janacek DP, Peters V, Kessel A, Dwivedi V, Carmeli-Weissberg M, Shaya F, Faigenboim-Doron A, Ung KL, Pedersen BP, Riov J, Klavins E, Dawid C, Hammes UZ, Ben-Tal N, Napier R, Sadot E, Weinstain R.
    Nature Biotechnology Online ahead of print, (2024).
    (PubMed)

  4. Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters.

    Ung KL, Schulz L, Stokes DL, Hammes UZ, Pedersen BP.
    Trends in Biochemical Sciences 48(11):937-948, (2023).
    (PubMed)

  5. Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions.

    Tschernoster N, Erger F, Kohl S, Reusch B, Wenzel A, Walsh S, Thiele H, Becker C, Franitza M, Bartram MP, Kömhoff M, Schumacher L, Kukat C, Borodina T, Quedenau C, Nürnberg P, Rinschen MM, Driller JH, Pedersen BP, Schlingmann KP, Hüttel B, Bockenhauer D, Beck B, Altmüller J.
    Genome Medicine 15(1):62, (2023).
    (PubMed)

  6. Auxin transport at the ER: Roles and structural similarity of PIN-FORMED and PIN-LIKES.

    Ung KL, Schulz L, Kleine-Vehn J, Pedersen BP, Hammes UZ.
    Journal of Experimental Biology 74(22):6893-6903, (2023).
    (PubMed)

  7. Structure and sucrose binding mechanism of the plant SUC1 sucrose transporter.

    Bavnhøj L, Driller JH, Zuzic L, Stange AD, Schiøtt B, Pedersen BP.
    Nature Plants 9(6):938-950 (2023).
    (PubMed)
    (Nature Plants News & Views Highlight)

  8. May the proton motive force be with you: A plant transporter review.

    Andersen CG, Bavnhøj L, Pedersen BP.
    Curr Opin Struct Biol. 79:102535, (2023).
    (PubMed)

  9. Structures and mechanism of the plant PIN-FORMED auxin transporter.

    Ung KL, Winkler M, Schulz L, Kolb M, Janacek DP, Dedic E, Stokes D, Hammes UZ, Pedersen BP.
    Nature 609(7927):605-610, (2022).
    (PubMed)
    (Nature Plants Research Highlight)

  10. Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective.

    Winkler MBL, Nel L, Frain KM, Dedic E, Olesen E, Pedersen BP.
    FEBS Letters 596(2):160-179, (2022).
    (PubMed)

  11. Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H+ symporter STP10.

    Bavnhøj L, Paulsen PA, Flores-Canales JC, Schiøtt B, Pedersen BP.
    Nature Plants 7(10):1409-1419, (2021).
    (PubMed)

  12. Structural basis for potassium transport in prokaryotes by KdpFABC.

    Sweet ME, Larsen C, Zhang X, Sclame M, Pedersen BP, Stokes DL.
    Proc Natl Acad Sci U S A. 118(29):e2105195118, (2021).
    (PubMed)

  13. An intracellular pathway controlled by the N-terminus of the pump subunit inhibits the bacterial KdpFABC ion pump in high K+ conditions.

    Dubey V, Stokes D, Pedersen BP, Khandelia H.
    J Mol Biol 433(15):167008, (2021).
    (PubMed)

  14. Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in Sugar Porter family.

    Custodio TF, Paulsen PA, Frain KM, Pedersen BP.
    Life Science Alliance 4(4):e202000858, (2021).
    (PubMed)

  15. Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein.

    Moesgaard L, Petersen D, Szomek M, Reinholdt P, Winkler MBL, Frain KM, Müller P, Pedersen BP, Kongsted J, Wüstner D.
    Biochemistry 59(45):4407-4420, (2020).
    (PubMed)

  16. Serine phosphorylation regulates the P-type potassium pump KdpFABC.

    Sweet ME, Zhang X, Erdjument-Bromage H, Dubey V, Khandelia H, Neubert TA, Pedersen BP, Stokes DL.
    eLife 9:e55480, (2020).
    (PubMed)

  17. Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.

    Winkler MBL, Kidmose RT, Szomek M, Thaysen K, Rawson S, Muench SP, Wüstner D, Pedersen BP.
    Cell 179:485-497, (2019).
    (PubMed)

  18. Namdinator - automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps.

    Kidmose RT, Juhl J, Nissen P, Boesen T, Karlsen JL, Pedersen BP.
    IUCrJ 6:526-531, (2019).
    (PubMed)

  19. The KdpFABC complex - K+ transport against all odds.

    Pedersen BP, Stokes DL, Apell HJ.
    Mol Membr Biol 35:21-38, (2019).
    (PubMed)

  20. Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily.

    Paulsen PA, Custódio TF, Pedersen BP.
    Nat Commun 10(1):407, (2019).
    (PubMed)

  21. Crystal structure of the potassium-importing KdpFABC membrane complex.

    Huang CS, Pedersen BP, Stokes DL.
    Nature 546(7660):681-685, (2017).
    (PubMed)

  22. Visualising the bacterium Streptococcus Pneumoniae.

    Engholm DH, Goodsell D, Kilian M, Andersen ES, Pedersen BP, Kjærgaard RS.
    Chapter in the anthology “The aesthetics of scientific data representation”, Routledge (2017).
    (Link)

  23. Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases.

    Focht D, Croll TI, Pedersen BP, Nissen P.
    Front Physiol. 8:202, (2017).
    (PubMed)

  24. Expression strategies for structural studies of eukaryotic membrane proteins.

    Lyons JA, Shahsavar A, Paulsen PA, Pedersen BP, Nissen P.
    Current Opinion in Structural Biology 38:137–144, (2016).
    (PubMed)

  25. Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.

    Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM.
    Proc Natl Acad Sci U S A. 113:4711-4716, (2016).
    (PubMed)

  26. Initiating heavy-atom-based phasing by multi-dimensional molecular replacement.

    Pedersen BP, Gourdon P, Liu X, Karlsen JL, Nissen P.
    Acta Cryst D 72:440-445, (2016).
    (PubMed)

  27. General qPCR and plate reader methods for rapid optimization of membrane protein purification and crystallization using thermostability assays.

    Tomasiak T, Pedersen BP, Chaudhary S, Rodriguez A, Colmanares YR, Roe-Zurz Z, Thamminana S, Tessema M, Stroud RM.
    Current Protocols in Protein Science 77:29.11.1-29.11.14 (2014).
    (PubMed)

  28. Large scale identification and categorization of protein sequences using Structured Logistic Regression.

    Pedersen BP*, Ifrim G*, Liboriussen P*, Axelsen KB, Palmgren MG, Nissen P, Wiuf C, Pedersen CNS.
    PLOS ONE 9:e85139, (2014).
    (PubMed)

  29. Structural basis for alternating access of a eukaryotic calcium/proton exchanger.

    Waight AB, Pedersen BP, Schlessinger A, Bonomi M, Chau BH, Roe-Zurz Z, Risenmay AJ, Sali A, Stroud RM.
    Nature 499(7456):107-110, (2013).
    (PubMed)

  30. Crystal structure of a eukaryotic phosphate transporter.

    Pedersen BP, Kumar H, Waight AB, Risenmay AJ, Roe-Zurz Z, Chau BH, Schlessinger A, Harries W, Sali A, Johri AK, Stroud RM.
    Nature 496(7446):533-536, (2013).
    (PubMed)

  31. Efficient expression screening of human membrane proteins in transiently transfected Human Embryonic Kidney 293S cells.

    Chaudhary S*, Pak JE*, Pedersen BP, Bang LJ, Zhang LB, Ngaw SM, Green RG, Sharma V, Stroud RM.
    Methods 55:273-280, (2011).
    (PubMed)

  32. Crystal structure of a copper-transporting PIB-type ATPase.

    Gourdon P*, Liu XY*, Skjørringe T, Morth JP, Møller LB, Pedersen BP, Nissen P.
    Nature 475:59-64, (2011).
    (PubMed)

  33. HiLiDe - Systematic Approach to Membrane Protein Crystallization in Lipid and Detergent.

    Gourdon P, Andersen JL, Hein KL, Bublitz M, Pedersen BP, Liu XY, Yatime L, Nyblom M, Nielsen TT, Olesen C, Møller JV, Nissen P, Morth JP.
    Crystal Growth & Design 11:2098-2106, (2011).
    (Link)

  34. A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.

    Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, Palmgren MG, Nissen P.
    Nat Rev Mol Cell Biol. 12:60-70, (2011).
    (PubMed)

  35. Structural identification of cation binding pockets in the plasma membrane proton pump.

    Ekberg K*, Pedersen BP*, Sørensen DM*, Nielsen AK, Veierskov B, Nissen P, Palmgren MG, Buch-Pedersen MJ.
    Proc Natl Acad Sci U S A. 107:21400-21405, (2010).
    (PubMed)

  36. Structure determination using poorly diffracting membrane protein crystals - Lessons from the H+ and Na+,K+-ATPases.

    Pedersen BP, Morth JP, Nissen P.
    Acta Cryst D 66:309-313, (2010).
    (PubMed)

  37. P-type ATPases as drug targets: tools for medicine and science.

    Yatime L, Buch-Pedersen MJ, Musgaard M, Morth JP, Lund Winther AM, Pedersen BP, Olesen C, Andersen JP, Vilsen B, Schiøtt B, Palmgren MG, Møller JV, Nissen P, Fedosova N.
    Biochim Biophys Acta 1787:207-220, (2009).
    (PubMed)

  38. Protons and how they are transported by proton pumps.

    Buch-Pedersen MJ, Pedersen BP, Nissen P, Palmgren MG.
    Pflügers Archiv - European Journal of Physiology 457:573-579, (2009).
    (PubMed)

  39. Crystal structure of the plasma membrane proton pump.

    Pedersen BP*, Buch-Pedersen MJ*, Morth JP, Palmgren MG, Nissen P.
    Nature 450(7172):1111-1114, (2007).
    (PubMed)
    (Nature News & Views)

  40. Crystal structure of the sodium-potassium pump.

    Morth JP, Pedersen BP, Toustrup-Jensen MS, Sørensen TL, Petersen J, Andersen JP, Vilsen B, Nissen P.
    Nature 450(7172):1043-1049, (2007).
    (PubMed)
    (Nature News & Views)